The puzzling mechanism of compensatory lung growth

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Compensatory Lung Growth After Pneumonectomy

Pneumonectomy, the surgical removal of a lung, elicits a number of anatomical changes within the thoracic cavity that augments the diffusion capacity of the remaining lung. Pneumonectomy directs the entire cardiac output into the remaining lung and creates an empty hemithorax that results in a shift of the mediastinum toward the vacated thoracic compartment. In a number of experimental animal m...

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Signals and mechanisms of compensatory lung growth.

Growth of the lung involves unique structure-function interactions not seen in solid organs. Mechanical feedback between the lung and thorax constitutes a major signal that sustains developmental as well as compensatory lung growth. After the loss of lung units as by pneumonectomy (PNX), increased mechanical stress and strain on the remaining units induce adaptive responses to augment oxygen tr...

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Invited Review HIGHLIGHTED TOPIC Lung Growth and Repair Signals and mechanisms of compensatory lung growth

Hsia, Connie C. W. Signals and mechanisms of compensatory lung growth. J Appl Physiol 97: 1992–1998, 2004; doi:10.1152/japplphysiol.00530.2004.— Growth of the lung involves unique structure-function interactions not seen in solid organs. Mechanical feedback between the lung and thorax constitutes a major signal that sustains developmental as well as compensatory lung growth. After the loss of l...

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Effects of retinoic acid on compensatory lung growth

BACKGROUND We investigated the effect of Retinoic acid in the growth of contralateral lung after pneumonectomy. METHODS Twenty one adult male Wistar albino rats from the same colony were used. They were divided into three groups (Group A, B and C). Group A undergone only left posterolateral thoracotomy. In Group B and C, the rats were subjected to left posterolateral thoracotomy and left pneu...

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ژورنال

عنوان ژورنال: Stem Cell Investigation

سال: 2018

ISSN: 2313-0792

DOI: 10.21037/sci.2018.03.01